|
|
(2E,6E)-farnesyl_diphosphate <=> presqualene_diphosphate + diphosphate
|
2.5.1.103
presqualene diphosphate synthase
2.5.1.21
squalene synthase
2.5.1.96
4,4'-diapophytoene synthase
|
–
–
–
|
| |
BRENDA:
BR49808
KEGG:
R00702
MetaCyc:
RXN-12263
SABIO-RK:
1080
|
|
|
|
5alpha-cholesta-7,24-dien-3beta-ol <=> Zymosterol
|
5.3.3.5
cholestenol Delta-isomerase
|
–
|
| |
BRENDA:
BS399747
KEGG:
R04804
MetaCyc:
RXN66-320
SABIO-RK:
4455
|
|
|
|
Zymosterol + NADP+ <=> H+ + zymosterone + NADPH
|
1.1.1.270
3beta-hydroxysteroid 3-dehydrogenase
1.1.1.51
3(or 17)beta-hydroxysteroid dehydrogenase
1.1.1.62
17beta-estradiol 17-dehydrogenase
|
–
–
–
|
| |
BRENDA:
BS374946
KEGG:
R12405
MetaCyc:
RXN66-319
|
|
|
|
squalene + diphosphate + NADP+ <=> presqualene_diphosphate + NADPH + H+
|
1.3.1.96
Botryococcus squalene synthase
1.3.1.97
botryococcene synthase
2.5.1.21
squalene synthase
|
–
–
–
|
| |
BRENDA:
BR48481
KEGG:
R02872
MetaCyc:
RXN-13724;
RXN66-281
|
|
|
|
4alpha-carboxy-4beta-methyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP+ <=> 3-dehydro-4-methylzymosterol + NADPH + CO2
|
1.1.1.170
3beta-hydroxysteroid-4alpha-carboxylate 3-dehydrogenase (decarboxylating)
|
–
|
| |
BRENDA:
BS422640
KEGG:
R07494
MetaCyc:
RXN66-313
|
|
|
|
(3S)-2,3-epoxy-2,3-dihydrosqualene <=> lanosterol
|
5.4.99.17
squalene---hopene cyclase
5.4.99.7
lanosterol synthase
|
–
–
|
| |
BRENDA:
BR254
KEGG:
R03199
MetaCyc:
LANOSTEROL-SYNTHASE-RXN
SABIO-RK:
3027
|
|
|
|
4alpha-carboxy-5alpha-cholesta-8,24-dien-3beta-ol + NADP+ <=> zymosterone + NADPH + CO2
|
1.1.1.170
3beta-hydroxysteroid-4alpha-carboxylate 3-dehydrogenase (decarboxylating)
|
–
|
| |
BRENDA:
BS422642
KEGG:
R12404
MetaCyc:
RXN66-318
|
|
|
|
5alpha-Cholest-7-en-3beta-ol + NADP+ <=> 5alpha-cholesta-7,24-dien-3beta-ol + NADPH + H+
|
1.3.1.72
Delta24-sterol reductase
|
–
|
| |
BRENDA:
BR29448
KEGG:
R05703
MetaCyc:
RXN66-321
|
|
|
|
lanosterol + reduced_flavodoxin + O2 <=> 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + formate + flavin + H2O
|
1.14.14.154
sterol 14alpha-demethylase
|
–
|
| |
BRENDA:
BS186735
KEGG:
R05640
|
|
|
|
5alpha-Cholest-7-en-3beta-ol + ferricytochrome_b5 + O2 + H+ <=> 7-dehydrocholesterol + ferricytochrome_b5 + H2O
|
1.14.19.20
Delta7-sterol 5(6)-desaturase
|
–
|
| |
BRENDA:
BS258666;
BS432737
KEGG:
R07215
MetaCyc:
1.14.21.6-RXN
SABIO-RK:
14442
|
|
|
|
4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP+ <=> 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + NADPH + H+
|
1.3.1.70
Delta14-sterol reductase
|
–
|
| |
BRENDA:
BR29447
KEGG:
R05639
MetaCyc:
RXN66-306
|
|
|
|
cholesterol + NADP+ <=> 7-dehydrocholesterol + NADPH + H+
|
1.3.1.21
7-dehydrocholesterol reductase
|
–
|
| |
BRENDA:
BR33764
KEGG:
R01456
MetaCyc:
RXN66-323
SABIO-RK:
1634
|
|
|
|
cholesterol + O2 + NADPH + H+ <=> 7-dehydrocholesterol + NADP+ + H2O
|
1.14.19.21
cholesterol 7-desaturase
|
–
|
| |
BRENDA:
BR51371
KEGG:
R11008
MetaCyc:
RXN-16379
|
|
